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Asthma exacerbations in children: Depending on symptom severity, they should be treated promptly and aggressively at home and/or the Emergency Department


Orapred ODT: Dosing for treatment of severe asthma exacerbation is consistent with NHLBI Guidelines

NHLBI Guidelines recommend that prednisolone be dosed at 1-2 mg/kg/day when indicated in pediatric asthma patients. While doses vary by patient, the dosing guide at the right lists suggested doses of Orapred ODT recommended to meet these guidelines for children of various weights.

Do not break or use partial Orapred ODT tablets.

 

Indication

Important Safety Information

Do not break or use partial Orapred ODT tablets.

Orapred is contraindicated in patients with systemic fungal infections. Administration of live or live, attenuated vaccines is contraindicated in patients receiving immunosuppressive doses of corticosteroids. Killed or inactivated vaccines may be administered, however, the response to such vaccines cannot be predicted. Immunization procedures may be undertaken in patients who are receiving corticosteroids as replacement therapy, e.g., for Addison’s disease. Orapred may cause mood swings. Adverse effects of Orapred include the following: endocrine (including development of cushingoid state, increased requirements for insulin or oral hypoglycemic agents in diabetic patients, manifestations of latent diabetes mellitus); fluid and electrolyte disturbances (including fluid retention, hypertension); gastrointestinal (including peptic ulcer with possible perforation and hemorrhage); increased appetite; and weight gain.

References:
1: Rachelefsky G. Treating exacerbations of asthma in children: the role of systemic corticosteroids. Pediatr.2003;112:382-397.

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